Cidofovir anal application

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Free to read. To evaluate the safety and efficacy of topical cidofovir for treatment of high-grade squamous perianal and vulvar intraepithelial neoplasia PAIN and VIN lesions in HIV-positive individuals. Twenty-four men and 9 women 8 with high-grade VIN as well were enrolled.
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Topical therapies for the treatment of anal high-grade squamous intraepithelial lesions

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Topical therapies for the treatment of anal high-grade squamous intraepithelial lesions

Many different treatment modalities have been suggested and studied. All treatment modalities demonstrated some initial regression of AIN after treatment; however, recurrence rates were high especially in HIV-positive patients. Many of the studies suffered from significant bias which prevented direct comparison. For this reason, much of the current evidence is derived from this population. Most treatments also have significant side effects that limit their acceptability for long-term use.
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Study record managers: refer to the Data Element Definitions if submitting registration or results information. Antiviral drugs,, such as cidofovir, act against viruses and may stop these lesions from becoming cancer. Patients apply topical cidofovir to the perianus once daily on days
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Anal cancer may be prevented by treating anal high-grade squamous intraepithelial lesions HSIL. Ablative therapies are the most commonly used treatments, but they may not be appropriate for all patients including those with extensive HSIL or bleeding diastheses. Researchers have studied topical therapies for human papillomavirus related lesions including anal HSIL. These therapies include patient-applied 5-fluorouracil, imiquimod and cidofovir, and provider-applied trichloroacetic acid.
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